Clinical exome sequencing is becoming more widely adopted every day. Based on the evidence offered hospitals, professional organizations, and even insurance companies are adopting and/or supporting the clinical exome for themselves. How might you convince someone who is still skeptical though? What evidence is available for the clinical and/or cost-effectiveness in exome. In this episode, we discuss some of the most compelling evidence available which supports clinical use of exome sequencing to give you the tools you need to convince the skeptics around you!